The Brain Doesn’t Like Diets

The Brain Doesn’t Like Diets

Not easy to lose weight if our neurons prevent it! This new study reveals that our brain does not like food restriction and that constrained by a diet it prevents the loss of calories.

The Brain Does Not Like Diets

Diets can be ineffective in losing weight because key brain cells act to prevent us from burning calories when foods become too scarce, according to the results of a study published in eLife magazine. These findings were obtained in mice.

Researchers at the Cambridge University laboratories in the UK tested the role of a group of neurons in the hypothalamus. These neurons related to neuropeptides (AGRP) are known for their major role in regulating appetite, when they are activated they make us eat, but when completely inhibited they can lead to almost complete anorexia.

The team used a genetic trick to transform the AGRP neurons into the mouse so that they can handle them quickly and reversibly.

The Food deprivationĀ OnĀ Brain Stores Energy From The Body

Researchers have demonstrated that AGRP neurons are key factors in the caloric thermostat that regulates our weight by regulating the number of calories we burn. The results suggest that, when activated, these neurons give us hunger and lead us to eat, but when there is no food available, they act to save energy by limiting the number of calories we eat Burn and therefore our weight loss.

As soon as food is available and we start eating, the action of AGRP neurons is interrupted and our energy expenditure goes back to normal levels.

“Weight loss strategies are often ineffective because the body functions as a thermostat and couples the amount of calories we burn to the amount of calories we eat,” says Dr. Clemence Blouet of the Cambridge University Laboratory And author of the study. “When we eat less, our body compensates and burns fewer calories, making weight loss more difficult.”